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How Is The HERG Screening Market Expected To Grow In Terms Of Size?

The market size for HERG screening has significantly expanded in the last few years. It is projected to increase from $1.62 billion in 2024 to $1.84 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 13.7%. The escalation during the historic period is due to a surge in drug development activities, regulatory directives, a growing consciousness about cardiac safety, and an upward trend in cardiac disorder incidents.

In the coming years, the HERG screening market size is anticipated to witness a remarkable expansion. The market is projected to reach “$2.88 billion by 2029 with a compound annual growth rate (CAGR) of 11.9%. The forecasted growth is largely linked to the broadening scope of personalized medicine, an increase in the delegation of drug development tasks, the rise of emerging markets, as well as research and focus on non-cardiac safety assessments. Key emerging trends for the predicted period include advancements in in vitro models, incorporation of genomic and proteomic data, progression in computational methods, emphasis on pediatric drug safety, and collaborations aimed at data sharing and standardization.

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Which Factors Are Steering Growth In The HERG Screening Market?

The increasing prevalence of cardiac conditions is anticipated to drive the expansion of the HERG screening market. Also known as cardiovascular diseases, heart disorders encompass a series of ailments influencing the heart and blood vessels. These maladies can disrupt the functioning of the heart and potentially lead to severe health issues. Unhealthy lifestyles, elderly population, genetics, diabetes, and metabolic syndrome are central to the emergence of these disorders. HERG screening assists in recognizing potential pharmaceutical candidates, warding off dangerous cardiac incidents like life-threatening cardiac arrhythmias, especially torsade de pointes (TdP), and enhancing patient prognosis. For example, a report by the US-based Centers for Disease Control and Prevention in May 2023 revealed that 1 in 20 adults over the age of 20 have cardiovascular diseases, with 695,000 people diagnosed and 375,476 deaths. Additionally, a March 2022 report from the UK’s Office for National Statistics showed that 20,061 people died from heart attacks, marking an uptick from the prior year. Thus, the growing count of heart disorder patients is fueling the advancement of the HERG screening market.

How Is The HERG Screening Market Segmented Across Key Categories?

The herg screening market covered in this report is segmented –

1) By Type: Gene KCNH2, Mutant KCNH2

2) By Ion Channel: Voltage-Gated, Ligand Gated

3) By Applications: Antiarrhythmic, Antipsychotic, Antibiotics, Other Applications

Subsegments:

1) By Gene KCNH2: Wild-Type KCNH2, Recombinant KCNH2

2) By Mutant KCNH2: Mutations: Missense Mutations, Nonsense Mutations, Frameshift Mutations

What Key Trends Are Driving Growth In The HERG Screening Market?

Key players in the HERG screening market are focusing on developing new cutting-edge solutions such as GLP-certified HERG screening services, to improve cardiac safety evaluations in drug development procedures. These services involve the GLP-approved screening of the human ether-à-go-go related gene (hERG) using the traditional whole-cell patch-clamp method, ensuring the screening aligns with regulatory guidelines like ICH S7A and ICH S7B, integral for safety pharmacology research in drug development. For example, in August 2023, Metrion Biosciences Ltd., a British pharmaceutical firm, introduced its GLP-certified hERG screening service. The purpose of this service is to expand Metrion’s aid for the development of small molecule therapeutics and supplement the firm’s current cardiac safety service range. Moreover, this service uses the traditional whole-cell patch-clamp technique to evaluate potential cardiac risks before the initiation of Phase 1 clinical trials in humans, delivers regulatory advice for safety pharmacology research in drug development, and gives clients top-notch biology services for ion channel targets.

Which Firms Are Driving Innovation Within The HERG Screening Market?

Major companies operating in the HERG screening market are Eurofins-Cerep SA., Aviva Biosciences Inc., AstraZeneca Public Limited Company, Merck KGaA, Charles River Laboratories Inc., Abcam Public Limited Company, Molecular Devices LLC, Caliper Life Sciences Inc., Crprotex Limited, ChanTest Corporation, Creative bioarray Inc., Cellular Dynamics International Inc., Nanion Technologies, Essen Bioscience, ABR-Affinity BioReagents Inc., ACEA Biosciences Inc., Metrion biosciences Inc., Aurora Biomed Inc., Aureus Sciences, RedShift BioAnalytics, B’SYS GmbH, Cambridge Bioscience Ltd., Sophion Bioscience Inc., Fluxion Biosciences Inc., ChemAxon Ltd.

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How Do Regional Dynamics Influence The HERG Screening Market Performance?

North America was the largest region in the HERG screening market in 2024. Asia-Pacific is expected to be the fastest growing region in the forecast period. The regions covered in the HERG screening market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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