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How Does The Market Size Of The Deoxyribonucleic Acid (DNA) Manufacturing Industry Compare Between 2025 And 2029?
The market for deoxyribonucleic acid (DNA) manufacturing has experienced substantial expansion in recent years. Projections indicate a rise from $4.77 billion in 2024 to $5.58 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 16.9%. Historically, this expansion has been driven by factors such as the emergence of genomics research, the development of biotechnology and biopharmaceutical sectors, the proliferation of contract manufacturing organizations (CMOs), the broadening scope of CRISPR and gene editing technologies, and supportive government investments and programs.
The deoxyribonucleic acid (DNA) manufacturing market is projected to experience substantial expansion over the coming years. It is anticipated to reach $10.28 billion by 2029, exhibiting a compound annual growth rate (CAGR) of 16.5%. This projected growth is driven by factors such as the broadening of cell and gene therapy pipelines, a rise in drug discovery initiatives, growing biodefense efforts, increased expenditure on pandemic preparedness, and the worldwide integration of biomanufacturing supply chains. Key trends expected during this period involve the incorporation of next-generation sequencing (NGS), the evolution of mRNA and DNA vaccines, improvements in long-read and high-fidelity synthesis techniques, the application of automation and robotics in DNA manufacturing, and the emergence of next-generation enzymatic DNA synthesis (EDS).
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Which Factors And Drivers Are Influencing The Deoxyribonucleic Acid (DNA) Manufacturing Market In 2025?
The growing need for gene therapies is projected to boost the deoxyribonucleic acid (DNA) manufacturing market’s expansion in the future. Gene therapies involve methods for altering or substituting defective genes to manage or avert illnesses, while personalized medicine customizes medical care based on a person’s genetic makeup, biological traits, and lifestyle. This surge in gene therapy demand stems from the increasing occurrence of genetic conditions, including cystic fibrosis, sickle cell anemia, and specific forms of inherited blindness. Deoxyribonucleic acid (DNA) manufacturing facilitates gene therapies by supplying the essential high-quality, customized DNA sequences required for creating and administering therapeutic genes capable of rectifying or replacing defective genetic material in patients. For example, data from August 2024, provided by the Association of the British Pharmaceutical Industry, a UK-based trade association, anticipates a significant increase in eligible gene therapy patients in the UK, from 2,500 in 2021 to an estimated 10,000 annually by 2028. Consequently, the escalating demand for gene therapies is fueling the expansion of the deoxyribonucleic acid (DNA) manufacturing market.
What Are The Key Segments In The Deoxyribonucleic Acid (DNA) Manufacturing Market?
The deoxyribonucleic acid (DNA) manufacturing market covered in this report is segmented
1) By Type: Plasmid Deoxyribonucleic Acid (DNA), Synthetic Deoxyribonucleic Acid (DNA), Gene Synthesis, Oligonucleotide Synthesis
2) By Grade: Good Manufacturing Practices (GMP) Grade, Research And Development Grade
3) By Application: Cell And Gene Therapy, Vaccines, Oligonucleotide-Based Drugs, Other Applications
4) By End-Use: Pharmaceutical And Biotechnology Companies, Academic And Research Institutes, Contract Research Organizations
Subsegments:
1) By Plasmid Deoxyribonucleic Acid (DNA): GMP-Grade Plasmid DNA, Non-GMP-Grade Plasmid DNA, High Copy Number Plasmids, Low Copy Number Plasmids, Bacterial Fermentation-Based Plasmid Production, Transfection-Grade Plasmid DNA
2) By Synthetic Deoxyribonucleic Acid (DNA): Enzymatic DNA Synthesis, Chemical DNA Synthesis, Long DNA Fragments, Short DNA Fragments, Single-Stranded Synthetic DNA, Double-Stranded Synthetic DNA
3) By Gene Synthesis: Custom Gene Synthesis, Standard Gene Synthesis, Complex Gene Constructs, Codon Optimization Services, Gene Library Synthesis
4) By Oligonucleotide Synthesis: DNA Oligonucleotides, Modified Oligonucleotides, Long Oligonucleotides, PCR Primers, SiRNA And Antisense Oligos, Adapter And Linker Oligos
Which Ongoing Trends Are Expected To Shape The Deoxyribonucleic Acid (DNA) Manufacturing Market Outlook?
Major companies in the DNA manufacturing market are concentrating on developing innovative methods, such as GMP-grade plasmid DNA production, to improve the quality, safety, and scalability of gene and cell therapy applications. GMP-grade plasmid DNA production involves manufacturing plasmid DNA under Good Manufacturing Practice (GMP) conditions, which are regulatory guidelines that ensure the quality, safety, and consistency of biopharmaceutical products. For instance, in April 2025, ProBio Genomics Inc., a US-based contract development and manufacturing organization (CDMO), launched its GMP Plasmid DNA Manufacturing Services in Hopewell, encompassing in-house analytical testing, method development, and project management. This service features unique aspects like internal process development, analytical testing, method development, and project management, which eliminates the need for various suppliers and quickens development timelines. It guarantees a high-quality output with =85% supercoiled plasmid DNA content while minimizing contamination risks. ProBio also makes available GMP-like plasmids with a four-week delivery timeline, and full GMP-grade plasmids are provided within three months.
Which Industry Leaders Are Driving Innovation Across The Deoxyribonucleic Acid (DNA) Manufacturing Market?
Major companies operating in the deoxyribonucleic acid (DNA) manufacturing market are Thermo Fisher Scientific Inc., Merck KGaA, Lonza Group AG, Kaneka Corporation, Catalent Inc., Charles River Laboratories International Inc., WuXi Biologics Inc., AGC Biologics Inc., Integrated DNA Technologies Inc., GenScript Biotech Corporation, Takara Bio USA Inc., Twist Bioscience Corp., Ajinomoto Bio-Pharma Services, OriGene Technologies Inc., DNA Script SAS, Eurofins Genomics LLC, Touchlight Genetics Ltd., Elegen Inc., VGXI Inc., PlasmidFactory GmbH & Co. KG.
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Which Global Regions Are Influencing The Competitive Landscape Of The Deoxyribonucleic Acid (DNA) Manufacturing Market?
North America was the largest region in the deoxyribonucleic acid (DNA) manufacturing market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the deoxyribonucleic acid (DNA) manufacturing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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