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How Has the Phosphoramidite Market Size Changed, over the years?

In recent times, the size of the phosphoramidite market has shown a robust upward trend. It’s forecasted to expand from its current size of $1.01 billion in 2024 to $1.09 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 7.7%. The unprecedented growth during the historic period is a consequence of escalating demand for DNA and RNA synthesis, wider acceptance of mRNA-based therapies, increasing occurrence of genetic diseases, the surge in demand for synthetic biology, and significant augmentation in investments towards genomic research.

How Much Will the Phosphoramidite Market Be Worth in 2029?

In the forthcoming years, a robust expansion is forecasted for the phosphoramidite industry, which is projected to reach a market size of $1.44 billion in 2029, growing at a Compound Annual Growth Rate (CAGR) of 7.4%. This growth over the projected period can be ascribed to the escalating use of phosphoramidites, an increase in the demand for bespoke DNA and RNA synthesis, the need for high-purity phosphoramidites, a mounting emphasis on tailored medicine, and the proliferation of biopharmaceutical firms. Key trends anticipated during the forecast period encompass the extension of synthetic biology, the advent of innovative phosphoramidite chemistries, progress in genomic technologies, development strides in biotechnology, and the progression of individualized medicine.

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Which is the Largest Company in the Phosphoramidite Market?

Major companies operating in the phosphoramidite market are Thermo Fisher Scientific Inc., Agilent Technologies Inc., Aragen Life Sciences, Twist Bioscience, Innovassynth Technologies (I) Ltd., Tokyo Chemical Industry Co. Ltd. (TCI), Aurigene Services, Eurofins Genomics, LGC Biosearch Technologies, Link Technologies Ltd., Creative Biolabs, Biosynth Carbosynth, TriLink BioTechnologies, ChemGenes Corporation, Berry & Associates Inc., Lumiprobe Corporation, Hongene Biotech Corporation, Carbolink India Pvt. Ltd., PolyOrg Inc., Glen Research, Gene Link Inc., emp BIOTECH GmbH

What Are the Main Market Drivers in the Phosphoramidite Industry?

The phosphoramidite market is projected to surge due to the expansion of the biopharmaceutical sector. The biopharmaceutical sphere involves the investigation, formulation, production, and marketing of medical goods derived from biological sources, such as vaccines, gene therapies, monoclonal antibodies, and recombinant proteins. This expansion is attributed to advancements in biotech, escalating incidences of chronic illnesses, and increased investment in R&D. Innovations in biotech like gene editing and monoclonal antibody therapies have led to more efficient and focused treatments. The need for phosphoramidites will increase with the growth of the biopharmaceutical sector, as they play a significant role in creating DNA and RNA for gene therapies, mRNA vaccines, and oligonucleotide-based medicines. As acceptance and traction for these therapies rise, synthetic nucleic acids produced by phosphoramidites also become more necessary, prompting their increased utilization in biopharmaceutical research and production. For example, the central biopharmaceutical sector produced £46.7 ($58.4 billion) billion in revenue in 2022, according to the UK government, accounting for 43% of the life sciences industry’s overall earnings. Moreover, the sector supports more than 126,000 jobs and has seen a major increase in R&D investment. As a result, the growth of the biopharmaceutical market is fueling the expansion of the phosphoramidite market.

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How Is the Phosphoramidite Market Segments Structured?

The phosphoramidite market covered in this report is segmented –

1) By Type: Deoxyribonucleic Acid (DNA) Phosphoramidites, Ribonucleic Acid (RNA) Phosphoramidites, Labeled Phosphoramidites, Modifier Phosphoramidites, Other Types

2) By Synthesis Method: H-Phosphonate Method, Phosphoramidite Method, Trivalent Phosphorus Compounds Method

3) By Application: Gene Synthesis, Deoxyribonucleic Acid (DNA) Sequencing, Deoxyribonucleic Acid (DNA) Amplification

4) By End-User: Academic Research, Pharmaceutical Industry, Biotechnology Industry

Subsegments:

1) By Deoxyribonucleic Acid (DNA) Phosphoramidites: Standard DNA Phosphoramidites, Degenerate DNA Phosphoramidites, Methylated DNA Phosphoramidites, Backbone-Modified DNA Phosphoramidites

2) By Ribonucleic Acid (RNA) Phosphoramidites: Standard RNA Phosphoramidites, 2′-O-Methyl RNA Phosphoramidites, 2′-Fluoro RNA Phosphoramidites, 2′-O-TBDMS Protected RNA Phosphoramidites

3) By Labeled Phosphoramidites: Fluorescent-Labeled Phosphoramidites, Biotin-Labeled Phosphoramidites, Digoxigenin-Labeled Phosphoramidites, Radioisotope-Labeled Phosphoramidites

4) By Modifier Phosphoramidites: Amine-Modified Phosphoramidites, Thiol-Modified Phosphoramidites, Spacer Phosphoramidites, Azide-Modified Phosphoramidites

5) By Other Types: Chimeric Phosphoramidites, Phosphorothioate Phosphoramidites, PEGylated Phosphoramidites, Photo-Cleavable Phosphoramidites

What Strategic Trends Are Transforming the Phosphoramidite Market?

Prominent entities in the phosphoramidite industry are concentrating their efforts on the creation of enhanced DNA synthesis services to improve precision, speed, and sustainability, all while minimizing the generation of harmful waste in the production of DNA. DNA synthesis, which relies on enzymes rather than chemical reagents to generate DNA sequences, offers increased accuracy, speediness, and sustainability. This is exemplified by the recent announcement in April 2022, where US-based biotech firm Ansa Biotechnologies Inc. reported an oversubscribed Series A financing round amounting to $68 million, led by Northpond Ventures and supported by a range of new and continuing investors. These funds are aimed at hastening the progress of Ansa’s future enzymatic DNA synthesis technology, or phosphoramidite synthesis, as well as enlarging its research and development and manufacturing infrastructure, and rolling out a bespoke DNA synthesis service. This company, a spin-off from the University of California, Berkeley, employs a patented technique that ensures swift and precise synthesis of lengthy DNA sequences, addressing existent constraints within the sector.

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Which Global Regions Offer the Highest Growth in the Phosphoramidite Market?

North America was the largest region in the phosphoramidite market in 2024. Europe is expected to be the fastest-growing region during the forecast period. The regions covered in the phosphoramidite market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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This Report Delivers Insight On:

1. How big is the phosphoramidite market, and how is it changing globally?

2. Who are the major companies in the phosphoramidite market, and how are they performing?

3. What are the key opportunities and risks in the phosphoramidite market right now?

4. Which products or customer segments are growing the most in the phosphoramidite market?

5. What factors are helping or slowing down the growth of the phosphoramidite market?

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