Pharmaceuticals

Global Antisense & RNAi Therapeutics Industry Trends: Where the Market Is Headed by 2029

November 7, 2025 by Marketing Posting

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How Much Larger Is The Antisense & RNAi Therapeutics Market Expected To Become By 2029 Compared With Its 2025 Level?

The antisense & RNAi therapeutics market has experienced rapid expansion in its size over recent years. This market is expected to expand from $1.75 billion in 2024 to reach $1.93 billion in 2025, demonstrating a compound annual growth rate (CAGR) of 10.2%. Factors contributing to its historical growth include an increase in funding, progress in technologies, elevated healthcare expenditure, the swift expansion of the elderly demographic, and economic development within emerging markets.

The antisense & RNAi therapeutics market size is projected to experience rapid expansion in the coming years. This market is expected to reach $3.11 billion by 2029, achieving a compound annual growth rate (CAGR) of 12.8%. The anticipated growth during this forecast period stems from factors such as increased access to healthcare, the rising incidence of cancer, and a surge in demand for antisense and RNAi therapeutics prompted by COVID-19. Significant trends for the forecast period include concentrated efforts on the research and development of RNA therapeutics for orphan diseases, the adoption of nanoparticles, the creation of novel and refined antisense and RNAi therapeutics, and strategic collaborations with other companies to innovate products and generate revenue.

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Which Factors And Drivers Are Influencing The Antisense & RNAi Therapeutics Market In 2025?

The increasing incidence of coronary artery diseases, neurodegenerative disorders, and infectious diseases is expected to boost the demand for the antisense & RNAi therapeutics market. Gene suppression methods, such as RNA interference and antisense oligonucleotides, are utilized in treating various neurodegenerative conditions by correcting mutant genes. For example, in January 2024, a report issued by the American Heart Association, a US-based organization, highlighted that the age-adjusted death rate from cardiovascular diseases rose to 233.3 per 100,000, marking a 4.0% increase from the previous year. Thus, the growing prevalence of several neurodegenerative and infectious diseases is anticipated to spur the growth of the antisense & RNAi therapeutics market.

What Are The Emerging Segments Gaining Attention In The Antisense & RNAi Therapeutics Market?

The antisense & rnai therapeutics market covered in this report is segmented –

1) By Technology: RNA Interference, Antisense RNA

2) By Route Of Administration: Intravenous Injections, Intra-dermal Injections, Other Delivery Methods

3) By Indication: Oncology, Cardiovascular Diseases (CVDs), Respiratory Disorders, Neurological Disorders, Infectious Diseases, Other Indications

Subsegments:

1) By RNA Interference (RNAi): Small Interfering RNA (siRNA), Short Hairpin RNA (shRNA), Dicer-substrate siRNA, MicroRNA (miRNA) Based Therapeutics

2) By Antisense RNA: Antisense Oligonucleotides (ASOs), Morpholino Oligomers, Locked Nucleic Acids (LNAs), Gapmer Antisense Oligonucleotides

Which Market Trends Are Creating New Opportunities In The Antisense & RNAi Therapeutics Industry?

Leading companies within the antisense & RNAi therapeutics market are implementing strategic initiatives, such as collaborations and partnerships, to maintain their position in an increasingly competitive environment. A strategic collaboration is a business approach where two or more firms work together to achieve a shared goal or objective. For instance, in January 2023, Orbit Discovery Limited, a US-based company providing services for peptide discovery, collaborated with SanegeneBio Inc., a UK-based company developing novel RNAi-based medicines. This partnership aimed to identify tissue-specific delivery methods for RNA therapeutics for efficient gene knockdown, intending to build a portfolio of advanced RNAi therapeutics. The collaboration includes hit identification and cell-based internalization studies, with Sanegene having the choice to further develop the hits discovered from the screening activities, utilizing Orbit’s proprietary technology for rapid peptide lead discovery. Orbit Discovery’s distinctive peptide display engine allows for the screening of extensive peptide libraries, enabling quicker discovery times for pertinent peptide leads based on affinity and functional screens.

Who Are The Top Performing Companies In The Antisense & RNAi Therapeutics Market In Recent Years?

Major companies operating in the antisense & RNAi therapeutics market include Biogen Inc., Ionis Pharmaceuticals Inc., Alnylam Pharmaceuticals Inc., Arrowhead Pharmaceuticals Inc., Moderna Inc., Sanofi S.A., Dicerna Pharmaceuticals Inc., Arbutus Biopharma Corporation, Acuitas Therapeutics, Adhera Therapeutics Inc., EdiGene Inc., Sirnaomics Inc., Suzhou Ribo Life Science Co. Ltd, Biocon Limited, Quark Pharmaceuticals, GlaxoSmithKline Plc, Shanghai Junshi Biosciences Co. Ltd., AstraZeneca, Benitec Biopharma Limited, Silence Therapeutics, Dynacure, CN Bio Innovations, Sarepta Therapeutics, Mallinckrodt, Regeneron Pharmaceuticals Inc., Alcyone Lifesciences Inc., Bio-Path Holdings Inc, Calando Pharmaceuticals, Enzon Pharmaceuticals Inc, Celnova Pharma, Pfizer Inc., Taiba Pharma, Gen İlaç ve Sağlık Ürünleri A.Ş., Egypt Otsuka Pharmaceutical

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How Is Antisense & RNAi Therapeutics Market Demand Varying Across Different Regions?

North America was the largest region in the antisense & RNAi therapeutics market in 2024. The regions covered in the antisense & RNAi therapeutics market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa

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