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What Is the Forecast for the Oligonucleotide Synthesis Market Growth in 2025?

In recent times, the market size for oligonucleotide synthesis has observed quick expansion. The market, which was valued at $10.33 billion in 2024, is predicted to surge to $11.94 billion in 2025, experiencing a compound annual growth rate (CAGR) of 15.6%. The upward growth trend in the past years can be credited to the progress in biomedical research, therapeutic development, biotechnological breakthroughs, genomic research, and the rise in DNA technologies.

What Is the Forecast for the Oligonucleotide Synthesis Market Size Through 2029?

In the forthcoming years, a swift expansion is anticipated in the oligonucleotide synthesis market size, with projections putting it at $22.29 billion in 2029, reflecting a compound annual growth rate (CAGR) of 16.9%. The growth trajectory during the forecast period is anticipated to be driven by advancements in diagnostic tools, RNA interference (RNAi) therapies, regenerative medicine, applications of nanotechnology, and progress in gene editing. The projected period also expects to see significant trends such as targeted drug development, innovative delivery systems, automation in synthesis, the use of CRISPR-cas technology, and the rise of next-generation sequencing (NGS).

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What are the Key Market Players in Oligonucleotide Synthesis Market and How They’re Evolving?

Major companies operating in the oligonucleotide synthesis market include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE HealthCare Technologies Inc., Eurofins Scientific SE, Agilent Technologies Inc., Nitto Denko Avecia Inc., Alnylam Pharmaceuticals Inc., Maravai Life Sciences, LGC Limited, Ionis Pharmaceuticals Inc., GenScript Inc., Ajinomoto Bio-Pharma Services, Sarepta Therapeutics Inc., Integrated DNA Technologies Inc., Twist Bioscience Corporation, Eurogentec SA, Kaneka Eurogentec S.A., Biocomma Limited, Bio-Synthesis Inc., TriLink BioTechnologies Incorporated, Generi Biotech s.r.o., ATDBio Ltd., BioAutomation Corporation, Biolegio B.V., Dharmacon Research Inc.

What Are the Primary Growth Drivers in the Oligonucleotide Synthesis Market?

The growth of the oligonucleotide synthesis market is projected to be fueled by the increasing incidence of chronic diseases. Chronic diseases are defined as conditions that persist for at least a year, necessitating consistent medical care, and may progressively worsen over time. Oligonucleotides function to regulate gene expression involved in chronic diseases through several mechanisms. These can target mRNA, pre-mRNA, or non-coding RNA to manipulate splicing events, instigate degradation, or interfere with protein translation. For example, the World Health Organization, a specialized agency of the United Nations based in Switzerland, reported in September 2022 that there were 41 million deaths worldwide, accounting for 74% of all deaths due to non-communicable diseases (NCDs) or chronic diseases annually. The report detailed 17.9 million deaths from cardiovascular diseases, 9.3 million from cancer, 4.1 million from chronic respiratory diseases, and 2.0 million from diabetes. Thus, the elevation in the occurrence of chronic and rare diseases is stimulating the expansion of the oligonucleotide synthesis market.

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What Are the Leading Segments in the Global Oligonucleotide Synthesis Industry?

The oligonucleotide synthesis market covered in this report is segmented –

1) By Type: Custom Oligos, Predesigned Oligos

2) By Product Type: Oligonucleotides, Reagents, Equipment, Services, Purification, Modification

3) By Application: Therapeutic Applications, Research Applications, Diagnostic Applications

Subsegments:

1) By Custom Oligos: Long Oligonucleotides, Short Oligonucleotides, Modified Oligonucleotides

2) By Predesigned Oligos: Gene-Specific Oligos, Probe Oligos, Primers For PCR And RT-PCR

What Are the Key Market Trends in the Oligonucleotide Synthesis Industry?

Product innovation has emerged as a pivotal trend in the oligonucleotide synthesis market, with major players focussing on the development of novel products to consolidate their market presence. For example, Ansa Biotechnologies, Inc., a company based in the US specializing in the manufacture of complex DNA, rolled out Ansa Clonal DNA and Ansa DNA Fragments in July 2024. Ansa Clonal DNA facilitates clonal, flawless sequences of DNA up to 600 base pairs long, negating the need for assembly, and hence delivers unmatched precision for intricate synthetic biology projects. This product guarantees error-free and ready-to-use DNA sequences, positioning it as a trustworthy choice for scientific researchers. Ansa DNA Fragments provides sequence-verified linear double-stranded DNA fragments, which can also be up to 600 base pairs long, customized for a wide array of research uses. Ansa’s innovative enzymatic synthesis method consistently generates complex DNA structures, inclusive of repeats and secondary structures, with high adaptability.

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What Is the Regional Outlook for the Oligonucleotide Synthesis Market?

North America was the largest region in the oligonucleotide synthesis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oligonucleotide synthesis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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This Report Delivers Insight On:

1. How big is the oligonucleotide synthesis market, and how is it changing globally?

2. Who are the major companies in the oligonucleotide synthesis market, and how are they performing?

3. What are the key opportunities and risks in the oligonucleotide synthesis market right now?

4. Which products or customer segments are growing the most in the oligonucleotide synthesis market?

5. What factors are helping or slowing down the growth of the oligonucleotide synthesis market?

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