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#How Has The Nucleic Acid Based Gene Therapy Market Size Shifted, And What Is the Outlook Through 2034?
In recent times, there has been significant growth in the market size of nucleic acid-based gene therapy. This market is expected to expand from $0.81 billion in 2024 to $0.88 billion in 2025, presenting a compound annual growth rate (CAGR) of 9.4%. This growth experienced in the historical period is due to the increased understanding of human genetics, the rising demand for personalized medicine, an expanding portfolio of gene therapy products, governmental support for gene therapy, and applications in genetic disorder and cancer therapies.
How Much Will the Nucleic Acid Based Gene Therapy Market Be Worth in 2029?
Over the coming years, the nucleic acid based gene therapy market is predicted to undergo significant expansion. The projection for growth is an increase to $1.33 billion by 2029, maintaining a compound annual growth rate (CAGR) of 10.7%. Various factors are contributing to this projected growth during the forecast period, including an expansion of indications, growth in funding, the impact of patient advocacy and awareness, increases in investment into gene therapy research and development, and the broadening scope of gene therapy applications, especially in rare diseases. Key trends identified in the forecast period encompass ex vivo gene editing, advancements in in vivo gene editing, combination treatments, targeted delivery systems, gene editing designed for rare diseases, and non-viral vectors.
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Which is the Largest Company in the Nucleic Acid Based Gene Therapy Market?
Major companies operating in the nucleic acid based gene therapy market include Celsion Corporation, Wave Life Sciences, Imugene Ltd., Caperna LLC, Phylogica Limited, Protagonist Therapeutics Inc., Benitec Biopharma Ltd., EGEN, BioMedica, Transgene SA, Copernicus Therapeutics Inc., 4D Molecular Therapeutics Inc., Abeona Therapeutics Inc., Alnylam Pharmaceuticals Inc., Amgen Inc., Beam Therapeutics Inc., BioNTech SE, Bluebird Bio Inc., CRISPR Therapeutics AG, Editas Medicine Inc., Genevant Sciences Inc., Homology Medicines Inc., Intellia Therapeutics Inc., Ionis Pharmaceuticals Inc., MaxCyte Inc., Moderna Inc., Novartis International AG, Orchard Therapeutics plc, Precision BioSciences Inc., REGENXBIO Inc.
What Are the Main Market Drivers in the Nucleic Acid Based Gene Therapy Industry?
The boost in financial assistance from both government and corporate sectors is anticipated to spur the need for nucleic acid-based gene therapy. Such therapeutics are equivalents of naturally present acids or proteins that regulate genetic expression. Conventional therapies offer no cure for conditions such as cystic fibrosis, hemophilia, sickle cell anemia, thalassemia, and diabetes. The foundation of these drugs is genetic profiling and pinpointing molecular targets. Nucleic acid-based medicines demonstrate a higher potential for tackling these ailments as they focus on the genetic origins of diseases and offer a lasting cure. The surge in financial backing from government and business entities invested in the gene therapy market is set to boost the demand for this therapy. For instance, in August 2022, the National Institute of Health (NIH) pledged to invest an annual $34 million over the next five years to advance HIV treatment research. This governmental support for gene therapies is likely to accelerate the growth of the nucleic acid-based gene therapy market.
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How Is the Nucleic Acid Based Gene Therapy Market Segments Structured?
The nucleic acid based gene therapy market covered in this report is segmented –
1) By Technology: Anti-Sence and Anti-Gene, Short Inhibitory Sequences, Gene Transfer Therapy, Nucleoside Analogs, Ribozymes, Aptamers, Other Technologies
2) By Application: Oncology, Muscular Dystrophy/ Muscular Disorders, Rare Diseases
3) By End User: Hospitals And Clinics, Academic And Research Institutes
Subsegments:
1) By Anti-Sense And Anti-Gene: Oligonucleotide Therapeutics, Peptide Nucleic Acids (PNA), Morpholino Oligomers (MO)
2) By Short Inhibitory Sequences (siRNA): Synthetic siRNA, Encapsulation/Delivery Systems for siRNA, Target-specific siRNA Therapies
3) By Gene Transfer Therapy: Viral Vectors (Adenovirus, Lentivirus, Retrovirus, AAV), Non-Viral Vectors (Liposomes, Electroporation, Gene Gun)
4) By Nucleoside Analogs: Purine Analogs, Pyrimidine Analogs
5) By Ribozymes: Trans-Splicing Ribozymes, Hammerhead Ribozymes
6) By Aptamers: RNA Aptamers, DNA Aptamers, Small Molecule Binding Aptamers
7) By Other Technologies: CRISPR-based Gene Editing, Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector Nucleases (TALENs)
What Strategic Trends Are Transforming the Nucleic Acid Based Gene Therapy Market?
In March 2023, US biotech firm Moderna, Inc. formed a strategic alliance with Generation Bio. Their objective with this alliance is to create new nucleic acid-based medicines, including types that can be delivered to immune cells, thereby speeding up their individual pipelines for non-viral genetic medications. This collaboration also encompasses funding for all related research and development activities, with a prepaid commitment for research undertakings. Generation Bio is another American biotechnology company that specializes in nucleic acid-based gene therapy.
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Which Global Regions Offer the Highest Growth in the Nucleic Acid Based Gene Therapy Market?
North America was the largest region in the nucleic acid-based gene therapy market in 2023. Western Europe was the second-largest region in the nucleic acid-based gene therapy market report. The regions covered in the nucleic acid based gene therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, and Africa.
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This Report Delivers Insight On:
1. How big is the nucleic acid based gene therapy market, and how is it changing globally?
2. Who are the major companies in the nucleic acid based gene therapy market, and how are they performing?
3. What are the key opportunities and risks in the nucleic acid based gene therapy market right now?
4. Which products or customer segments are growing the most in the nucleic acid based gene therapy market?
5. What factors are helping or slowing down the growth of the nucleic acid based gene therapy market?
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