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What fueled the previous growth in the therapeutic proteins market?

The market size for therapeutic proteins has seen significant acceleration in its growth over past few years. It’s projected to expand from a worth of $140.96 billion in 2024 to a value of $158.16 billion in 2025, suggesting a compound annual growth rate (CAGR) of 12.2%. This impressive expansion during the historic period can be credited to the progress in protein engineering, wider application in treating chronic diseases, the introduction of immunotherapy, advancements in recombinant DNA technology, as well as targeted therapies for cancer.

What will be the therapeutic proteins market size in the future?

The market size of therapeutic proteins is projected to witness significant expansion in the upcoming years, reaching up to $257.4 billion by 2029, with a Compound Annual Growth Rate (CAGR) of 12.9%. This growth during the forecast period is expected to be driven by factors such as regulatory changes, advanced delivery systems, integration of gene editing, development of biobetters, and evolution of immunotherapy. The major trends set to govern the period of forecast comprise enhancements in regulatory structure, improvements in delivery systems, breakthroughs in biotechnology, personalized medication, and a stronghold of monoclonal antibodies.

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What main drivers are fueling expansion in the therapeutic proteins market?

Technological progress in protein-based drug development is propelling the therapeutic proteins market forward. Since therapeutic proteins cannot be synthesized chemically, genetic engineering and recombinant DNA technology are required for their production in living cells or organisms. Glycoengineering, pegylation, Fc-fusion, albumin fusion, and albumin drug conjugation are examples of protein-engineering platform technologies that enhance the production yield, purity of the product, circulating half-life, targeting, and functionality of therapeutic proteins drugs. Drugs like belimumab, ipilimumab, taliglucerase alfa, albiglutide, and recombinant human coagulation factor IX are some of the therapeutic proteins drugs that have successfully employed protein engineering technologies and been approved by the FDA in the last five years.

What key areas define the segmentation of the global therapeutic proteins market?

The therapeutic proteins market covered in this report is segmented –

1) By Product Type: Insulin, Fusion Protein, Erythropoietin, Interferon, Human Growth Hormone, Follicle Stimulating Hormone

2) By Function: Enzymatic And Regulatory Activity, Special Targeting Activity, Vaccines, Protein Diagnostics

3) By Application: Metabolic Disorders, Immunologic Disorders, Hematological Disorders, Cancer, Hormonal Disorders, Genetic Disorders, Other Applications

Subsegments:

1) By Insulin: Rapid-Acting Insulin, Short-Acting Insulin, Intermediate-Acting Insulin, Long-Acting Insulin

2) By Fusion Protein: Tnf-Alpha Inhibitors, Anti-Cd20 Fusion Proteins, Other Targeted Fusion Proteins

3) By Erythropoietin: Epoetin Alpha, Darbepoetin Alfa, Other Erythropoietin Variants

4) By Interferon: Interferon Alpha, Interferon Beta, Interferon Gamma

5) By Human Growth Hormone: Somatropin, Somatrem

6) By Follicle Stimulating Hormone: Follitropin Alpha, Follitropin Beta

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Who are the dominant players expanding their reach in the therapeutic proteins market?

Major companies operating in the therapeutic proteins market include Pfizer Inc., Johnson & Johnson Services Inc., F. Hoffmann-La Roche Ltd., Merck & Co. Inc., AbbVie Inc., Novartis International AG, Sanofi S.A, Bristol Myers Squibb Co., AstraZeneca plc, Abbott Laboratories, GlaxoSmithKline plc, Eli Lilly and Company, Boehringer Ingelheim International GmbH, Amgen Inc., Novo Nordisk A/S, Baxter International Inc., Teva Pharmaceutical Industries Ltd., CSL Behring LLC, Chugai Pharmaceutical Co. Ltd., Biogen Inc., Kyowa Kirin Co. Ltd., Oramed Pharmaceuticals Inc., Sandoz International GmbH, Hualan Biological Engineering Inc., Genentech Inc., ProBiogen AG, Diasome Pharmaceuticals Inc., Generex Biotechnology Corp., GeneScience Pharmaceuticals Co. Ltd.

How are evolving market trends shaping therapeutic proteins Strategies?

The rise in the number of biosimilar drugs within the international market is expected to curb the expansion of the therapeutic proteins market. The lapse of patents on therapeutic proteins, like monoclonal antibodies, paves the way for biosimilars in the industry. An example is the introduction of ALYMSY (bevacizumab-maly) in the U.S. by Amneal Pharmaceuticals, Inc., a U.S.-based generics and specialty pharmaceutical firm, in October 2022. These affordable alternatives to original biologics lead to a decrease in the revenue and sales of the therapeutic proteins market.

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Which regions are emerging as leaders in the therapeutic proteins market?

North America was the largest region in the therapeutic proteins market in 2024. The regions covered in the therapeutic proteins market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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