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What CAGR is Anticipated for the Alpha Mannosidosis Market During the Forecast Period, and Why?

The alpha mannosidosis market has grown rapidly. It is expected to rise from $15.1 billion in 2024 to $18.02 billion in 2025, at a CAGR of 19.3%. Historical growth was driven by urbanization, increasing demand for man-made fibers, and government support for the textile industry.

The alpha mannosidosis market is projected to see rapid growth in the next few years, expected to reach $34.52 billion by 2029 at a compound annual growth rate (CAGR) of 17.6%. The growth during this period is linked to global population growth and urbanization, increased e-commerce activity, rising demand for sportswear, greater penetration of organized retail in developing economies, and the growing influence of social media. Major trends in the forecast period include the increasing use of enzyme therapy, adoption of hematopoietic stem cell transplantation, and implementation of cisterna magna infusion.

Which Drivers Are Expected to Have the Greatest Impact on the alpha mannosidosis Market’s Growth?

The increasing focus on precision medicine is expected to drive the growth of the alpha mannosidosis market. Precision medicine, which tailors treatments based on an individual’s genetic makeup and lifestyle, is becoming more common in healthcare. The demand for personalized medicine, including targeted therapies for rare diseases like alpha mannosidosis, is rising. In 2023, the U.S. FDA approved 16 new personalized treatments for rare diseases, up from six in 2022. This increase in precision medicine approvals will contribute to the growth of the alpha mannosidosis market.

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Which Companies Are Poised to Shape the Future of the Alpha Mannosidosis Market?

Major companies operating in the alpha mannosidosis market include:

• Chiesi Farmaceutici S.p.A._x000D_

• Cipla_x000D_

• Daiichi Sankyo Company_x000D_

• Ultragenyx Pharmaceutical Inc_x000D_

• Mitsubishi Tanabe Pharma_x000D_

What Are the Latest Innovations and Trends Influencing the Alpha Mannosidosis Market?

Leading companies in the alpha mannosidosis market are concentrating on advancing enzyme replacement therapy to treat rare alpha-mannosidosis. This therapy works by supplying exogenous alpha-mannosidase, which helps mitigate the buildup of mannose-rich oligosaccharides in various tissues and organs—a hallmark of alpha-mannosidosis responsible for its pathological effects. For instance, in February 2023, Chiesi Global Rare Diseases, a US-based pharmaceutical company, introduced Lamzede (velmanase alfa), the first enzyme replacement therapy approved in the United States for treating alpha-mannosidosis. This rare genetic disorder results from a deficiency of the enzyme alpha-mannosidase, leading to symptoms outside the central nervous system. Lamzede mimics the function of the human body’s natural alpha-mannosidase enzyme, restoring normal cellular activity. Patients receive a 10 mg injection of Lamzede once a week.

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Which Key Segments of the Alpha Mannosidosis Market Are Poised for Growth and Innovation?

The alpha mannosidosis market covered in this report is segmented –

1) By Therapy Type: Bone Marrow Transplant (BMT), Enzyme Replacement Therapy (ERT), Other Therapies

2) By Indication: Type I, Type II, Type III

3) By End-User: Hospitals, Speciality Clinics

Subsegments:

1) By Bone Marrow Transplant (BMT): Autologous BMT, Allogeneic BMT

2) By Enzyme Replacement Therapy (ERT): Recombinant Enzymes, Long-acting Enzyme Formulations

3) By Other Therapies: Symptomatic Treatments, Gene Therapy, Supportive Care

What Regions Are Contributing Significantly to the Growth of the Alpha Mannosidosis Market?

North America was the largest region in the alpha mannosidosis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the alpha mannosidosis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

What Key Elements Shape the Definition of the Alpha Mannosidosis Market?

Alpha mannosidosis refers to a rare genetic disorder defined by the body’s cells’ inability to adequately break down specific groups of complex sugars. Numerous bodily organs and systems, including the central nervous system, are impacted by sugar buildup. The disease’s effects might vary greatly from person to person.

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