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What Are the Key Milestones in the Calciphylaxis Market’s Growth Trajectory From 2025 To 2034?

The market for calciphylaxis has seen swift expansion in the last few years. It is projected to increase from a value of $3.22 billion in 2024 to $3.55 billion in 2025, exhibiting a compound annual growth rate (CAGR) of 10.0%. The historic growth can be traced back to factors such as the growing incidence of chronic kidney disease, heightened cognizance of rare diseases, increasing government backing for research in rare diseases, improving regulatory conditions, and a rise in healthcare spending.

The market size for calciphylaxis is forecasted to witness significant expansion in the upcoming years. With a compound annual growth rate (CAGR) of 9.7%, it is expected to reach a value of $5.13 billion by 2029. This projected growth can be tied to factors such as an increasing aging population worldwide, the emergence of therapeutic innovations, broader access to dialysis in emerging regions, escalating investment in the development of drugs for rare diseases, and a rising prevalence of end-stage renal disease. The market’s growth is also likely to be influenced by key trends that include breakthroughs in dialysis and renal care, the evolution of treatments for mineral and bone disorder, progress in personalized medicine, advancements in biotech, therapeutic breakthroughs, and enhancement in healthcare policy.

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What Are the Primary Drivers Supporting the Market Growth of the Calciphylaxis Market?

The calciphylaxis market’s expansion is predicted to be fueled by the escalating occurrence of chronic kidney disease (CKD). CKD is a long-lasting condition characterized by a progressive loss of kidney function, which may ultimately result in kidney failure. This increasing prevalence of CKD is often tied to an aging demographic, higher incidences of diabetes and hypertension, poor lifestyle choices, and insufficient early detection and treatment of kidney diseases. Calciphylaxis is a pivotal sign of severe vascular complications in CKD, underlining the necessity for early intervention and better control of mineral imbalances to avert tissue death and related morbidity. For instance, data from the Australian Institute of Health and Welfare revealed in December 2024 that the mortality rates from CKD experienced a steady increase from 2021 to 2022, with growth of 4.2% in 2021 and 6.2% in 2022, the latter year being more significant. Thus, the growing number of CKD cases is fueling the calciphylaxis market’s growth. The calciphylaxis market’s growth is also being driven by the rise in obesity rates. Obesity, described as a health condition where excessive fat build-up heightens susceptibility to various diseases like heart disease, diabetes, and hypertension, has been growing. Factors contributing to this increase comprise of sedentary ways of living, high-calorie diet consumption, genetic factors, and lack of access to healthier food options. Obesity leads to an increased risk of calciphylaxis, especially in those with CKD, due to metabolic dysfunction, chronic inflammation, and vascular calcification, which amplify calcium-phosphate imbalance and cellular damage to the endothelium. According to the Centers for Disease Control and Prevention, a government agency in the US, in September 2023, the number of states with a 35% or greater adult obesity rate rose from 19 states in 2021 to 22 in 2022. With that, the rising rates of obesity are stimulating the expansion of the calciphylaxis market.

Which Primary Segments of the Calciphylaxis Market Are Driving Growth and Industry Transformations?

The calciphylaxis market covered in this report is segmented –

1) By Type: Non-Uremic Calciphylaxis, Ulcers And Wounds, Debridement Of Wounds

2) By Treatment: Drug Therapy, Hyperbaric Calciphylaxis Therapy

3) By Diagnosis: Deep Skin Biopsies, Blood Tests, Imaging

4) By End-Use: Hospital And Clinics, Homecare, Ambulatory Centers

Subsegments:

1) By Non-Uremic Calciphylaxis: Vascular Calcification, Soft Tissue Calcification, Cutaneous Manifestations

2) By Ulcers and Wounds: Skin Ulcers, Ischemic Wounds, Necrotic Ulcers, Pressure Ulcers

3) By Debridement Of Wounds: Surgical Debridement, Enzymatic Debridement, Autolytic Debridement, Mechanical Debridement, Biological Debridement

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Which Regions Are Key Players in the Growth of the #What Are the Primary Drivers Supporting the Market Growth of the Calciphylaxis Market?# Market?

North America was the largest region in the calciphylaxis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the calciphylaxis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

What Are the Most Significant Market Trends in the Calciphylaxis Market?

Leading businesses in the calciphylaxis market are concentrating on the creation of novel therapies, such as enzyme replacement therapy, to enhance the results of treatment and minimize the condition’s severity. Enzyme replacement therapy (ERT) is a technique for treating a missing or deficient enzyme in the body. It’s commonly utilized for treating uncommon genetic disorders where the body can’t produce a specific enzyme required for healthy cellular function. In October 2024, for example, US-based biopharmaceutical firm Inozyme Pharma Inc. reported positive preliminary findings from its Phase 1 SEAPORT 1 trial of INZ-701 in patients with end-stage kidney disease (ESKD). The initial data from the trial emphasizes the potential of INZ-701 to replenish enzyme activity essential for averting atypical mineralization, a major element in severe rare diseases. The therapy is engineered to replace enzymes targeting ENPP1 and ABCC6 deficiencies, which are linked to pathological calcium deposits in blood vessels and tissues.

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What Parameters Are Used to Define the Calciphylaxis Market?

Calciphylaxis refers to a rare, serious condition characterized by the calcification of small blood vessels, leading to skin necrosis and severe pain. It is used for studying vascular calcification disorders and developing targeted treatments to improve wound healing and pain management in affected patients.

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