How Will the Cholestatic Pruritus Market Grow? Key Trends and Opportunities for 2025 and Beyond
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How has the cholestatic pruritus market grown in recent years?
The market size for cholestatic pruritus has experienced robust growth in the past few years. The projection suggests an increase from $19.20 billion in 2024 to $20.28 billion in 2025, indicating a compound annual growth rate (CAGR) of 5.6%. Factors contributing to this growth during the historical phase include an increase in skin disorder cases, expanded investments in research and development, the need for effective treatments, heightened disease awareness, and supportive regulations.
How is the cholestatic pruritus market size expected to evolve during the forecast period?
Strong expansion is anticipated in the cholestatic pruritus market in the coming years, with an expected valuation of $24.97 billion by 2029, reflecting a 5.3% compound annual growth rate (CAGR). The projected increase in the market during this forecast period can be linked to various factors such as a growing elderly demographic, a rise in atopic dermatitis and urticaria cases, an uptick in the geriatric demographic, heightened incidences of chronic kidney diseases, and a growing prevalence of conditions leading to pruritus. The forthcoming period will witness prominent trends such as the advent of novel treatment alternatives, collaborations with leading corporations for cholestasis pruritus research, advances in treatment methodologies, extensive development of healthcare infrastructures, and technological breakthroughs.
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Which key drivers are propelling the cholestatic pruritus market’s growth?
The escalation in the occurrence of liver diseases is projected to stimulate the expansion of the cholestatic pruritus market in the future. The liver disease umbrellas various conditions that hinder liver functionality, encompassing infections, auto-immune disorders, genetic diseases, and damage from toxins that result in inflammation, scarring, or liver failure. The escalating incidence of liver diseases has been stoked by the rise in obesity, diabetes, alcohol consumption, viral hepatitis infections, and contact with toxins and environmental elements. Cholestatic pruritus facilitates the detection and control of liver diseases by acting as a pivotal symptom that specifies hampered bile flow, often instigating additional scrutiny and treatment of fundamental hepatic conditions. For example, in July 2023, as per the Office for Health Improvement and Disparities, a UK government body tasked with resolving health inequalities, hospital intakes for liver disease in England saw a 22% increase in 2022, escalating from 67,458 to 82,290. Hence, the escalating incidence of liver diseases will catalyze the expansion of the cholestatic pruritus market.
What are the market segments in the cholestatic pruritus industry?
The cholestatic pruritus market covered in this report is segmented –
1) By Disease Type: Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC), Intrahepatic Cholestasis of Pregnancy (ICP), Other Disease Types
2) By Treatment Type: Medications, Phototherapy, Other Treatment Types
3) By Route Of Administration: Oral, Topical, Injectable
4) By End-User: Hospitals, Clinics, Ambulatory Care Centers, Homecare
Subsegments:
1) By Primary Biliary Cholangitis (PBC): Early-Stage PBC, Advanced PBC, PBC With Cirrhosis, PBC With Liver Failure
2) By Primary Sclerosing Cholangitis (PSC): Classic PSC, PSC With Ulcerative Colitis, PSC With Bile Duct Strictures
3) By Intrahepatic Cholestasis of Pregnancy (ICP): Mild ICP, Severe ICP, ICP With Preterm Birth Risk
4) By Other Disease Types: Alcoholic Cholestasis, Drug-Induced Cholestasis, Viral Hepatitis-Induced Cholestasis, Genetic Cholestasis Disorders
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Which leading companies are shaping the growth of the cholestatic pruritus market?
Major companies operating in the cholestatic pruritus market are GlaxoSmithKline plc, Takeda Pharmaceutical Company Limited, Merck KGaA, Regeneron Pharmaceuticals Inc., Bausch Health Companies Inc., Incyte Corporation, Ipsen Pharma, Vanda Pharmaceuticals Inc., Medison Pharma Ltd., Mirum Pharmaceuticals Inc., Albireo Pharma Inc., Dipharma Francis S.r.l., Cara Therapeutics Inc., CANbridge Pharmaceuticals Inc., Escient Pharmaceuticals Inc., Tharimmune Inc., Vifor Fresenius Medical Care Renal Pharma, CymaBay Therapeutics Inc., ICE Pharma Inc., Aquatic Remedies Private Limited.
What are the key trends shaping the future of the cholestatic pruritus market?
Key players in the cholestatic pruritus industry are channeling their efforts into the creation of novel solutions such as oral formulations aimed at managing symptoms more effectively. They seek to enhance patient adherence to medication and supply targeted relief at the root of bile salt build-up and inflammation. Essentially, an oral formulation for treating cholestatic pruritus is a liquid drug mix prepared to lower bile acid build-up and mitigate intense itching in cholestasis patients. For instance, in March 2024, the U.S. Food and Drug Administration (FDA) gave approval to Mirum Pharmaceuticals Inc, a biopharmaceutical company based in the US, for their LIVMARLI (maralixibat) oral solution. This medication, designed for the treatment of cholestatic pruritus in patients five years and older suffering from progressive familial intrahepatic cholestasis (PFIC), is administered once daily. A breakthrough therapy designation for PFIC type 2 has been granted to this orally administered ileal bile acid transporter inhibitor. LIVMARLI is set to tremendously impact patients with cholestatic pruritus associated with PFIC by providing a crucial treatment alternative for those with the rarest subtypes.
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Which geographic areas are influencing the growth of the cholestatic pruritus market?
North America was the largest region in the cholestatic pruritus market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the cholestatic pruritus market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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