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How has the difficult-to-express proteins market grown over the years?

The market for challenging-to-express proteins has seen rapid expansion in recent years. It is projected to increase from $4.65 billion in 2024 to $5.22 billion in 2025, with a compound annual growth rate (CAGR) of 12.1%. This growth during the historic period can be attributed to factors such as an increase in demand for protein therapeutics, obstacles in drug development, advancements in biopharmaceuticals, technological boundaries, along with developments in gene editing and engineering.

What Is the forecasted market size and growth rate for the difficult-to-express proteins market?

The market for difficult-to-express proteins is projected to experience swift expansion in the coming years, with its size predicted to reach $8.05 billion by 2029, growing at a compound annual growth rate (CAGR) of 11.4%. The projected growth during this period can be linked to advancements in unique expression systems, next-generation gene-editing tools, enhanced cell-free systems, advanced protein engineering, and the integration of artificial intelligence and machine learning. Key trends anticipated during the forecast period encompass novel protein folding technologies, the augmented use of synthetic biology, targeted protein adjustment, advancements in biophysical characterization, and the increasing application of CRISPR/CAS technology.

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What are the major factors driving growth in the difficult-to-express proteins market?

The surging interest in recombinant proteins is predicted to expedite the expansion of the difficult-to-express protein market in the future. A recombinant protein is a protein that has been developed through the modification of recombinant DNA (deoxyribonucleic acid) to contain the genetic code of a target protein. Difficult-to-express proteins are harnessed in the synthesis of recombinant proteins to investigate their specific activities, how they interact with other proteins, and to aid in the creation of novel treatments for intricate medical conditions. For example, Amgen Inc., a biopharmaceutical company based in the United States, reported in their 2022 annual report that Prolia (Denosumab), a recombinant human monoclonal antibody (protein), experienced a 12% surge in annual sales, prompting $3,628 million in 2022, up from $3,248 million the previous year. Hence, the escalating demand for recombinant proteins is driving the growth of the difficult-to-express protein market.

What key areas define the segmentation of the global difficult-to-express proteins Market?

The difficult-to-express proteins market covered in this report is segmented –

1) By Protein: Proteases, Kinases, Membrane Proteins, Other Proteins

2) By Expression Of Difficult Proteins: Disulfide-bonded Protein Expression, Membrane Protein Expression, Toxic Protein Expression, Target Protein Insolubility

3) By Technology: Cell-free Protein Synthesis, Prokaryotic Expression Systems, Small Ubiquitin-like Modifier (SUMO) Fusion System, Gene Fusion Systems, Other Technologies

4) By Application: Drug Discovery, Protein Purification, Protein Therapeutics, Disease Diagnostics And Monitoring, Other Applications

Subsegments:

1) By Proteases: Serine Proteases, Cysteine Proteases, Aspartic Proteases, Metalloproteases

2) By Kinases: Receptor Tyrosine Kinases, Serine Or Threonine Kinases, Cyclin-Dependent Kinases

3) By Membrane Proteins: G-Protein Coupled Receptors (GPCRs), Ion Channels, Transporters

4) By Other Proteins: Transcription Factors, Structural Proteins, Enzymes

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What are the top market players propelling the growth of the difficult-to-express proteins industry?

Major companies operating in the difficult-to-express proteins market include Thermo Fisher Scientific Inc., Merck KGaA, Lonza Group Ltd, Catalent Inc., Sartorius AG, Charles River Laboratories International Inc., Bio-Rad Laboratories Inc., Samsung Biologics Co. Ltd., Bio-Techne Corp., GenScript Biotech Corporation, Ajinomoto Bio-Pharma Services, Novasep Holding SAS, Rentschler Biopharma SE, BioLegend Inc., Codexis Inc., Enzo Biochem Inc., Sino Biological Inc., Horizon Discovery Ltd., Creative Biolabs Inc., OriGene Technologies Inc., Celonic AG, Cube Biotech GmbH, Lucigen Corporation, Batavia Biosciences Inc., Cytovance Biologics Inc., Alloy Therapeutics Inc., Aragen Bioscience Inc., Selexis SA, LifeSensors Inc., Bionova Scientific Inc.

What are the key trends shaping the future of the difficult-to-express proteins market?

Innovative technology advancements are increasingly becoming a significant trend in the difficult-to-express protein market. Most major companies in this sector are concentrating their efforts on technological innovation in order to maintain their market standing. It is noteworthy that in January 2023, Evozyne, an American biotech company, unveiled its cutting-edge AI model, the Protein Transformer Variational AutoEncoder, specifically developed for the design of therapeutic proteins. This innovative approach offers an effective platform for the training and implementation of large language models in the realm of biology. Ultimately, this novel deep learning approach opens up unexplored avenues for the data-guided design of engineered proteins with intended functionality.

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What regions are dominating the difficult-to-express proteins market growth?

North America was the largest region in the difficult-to-express proteins market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the difficult-to-express proteins market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa

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