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How has the human liver model market size evolved in recent years?

In recent times, the market size of the human liver model has experienced a swift expansion. The market value is estimated to increase from $2.34 billion in 2024 to $2.63 billion in 2025, with a compound annual growth rate (CAGR) of 12.2%. This exceptional growth during the historical period is the consequence of a surge in requirements for drug growth, progress in biotechnology, alternatives to animal testing, a rise in liver illness, and regulatory demands.

What are the predictions for the human liver model market size in the coming years?

Over the coming years, the market for human liver models is projected to experience swift expansion. By 2029, its size is set to reach $4.41 billion, reflecting a compound annual growth rate (CAGR) of 13.8%. This surge during the forecast period can be linked to factors such as the incorporation of artificial intelligence and machine learning, the use of patient-derived liver models, groundbreaking developments in bioengineering, mandates for drug safety and toxicity testing, and the advent of virtual clinical trials. Other notable trends in this forecast period involve the synthesis of multiple organ models, advancements in 3D bioprinting, the capacity for high-throughput screening, improvements in vascularization and blood flow, as well as ethical and regulatory compliance.

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What key factors are fueling the growth of the human liver model market?

The burgeoning instances of liver ailments are anticipated to drive the expansion of the human liver model market. Any disorder that hinders the liver’s operation or impairs its effectiveness is classified as liver disease. Human liver models, a budding research field, hold promise in enhancing understanding of liver diseases and aiding in drug development. Consequently, the escalating cases of liver maladies are boosting the human liver model’s market growth. For example, Caner Australia, a government cancer body based in Australia, reported in September 2022 that approximately 2,905 new liver cancer cases were identified in the country in 2022, including 2,113 males and 792 females. Moreover, it is projected that the chance of contracting liver cancer by the age of 85 will be 1 in 103 (or 0.97%) in 2022, increasing to 1 in 70 or 1.4% for males, and 1 in 195 or 0.51% for females. Thus, the increasing incidence of liver ailments is driving the growth of the human liver model market.

How is the global human liver model market divided into key segments?

The human liver model market covered in this report is segmented –

1) By Product: Liver Organoids, Liver-On-A-Chip, 2D Models, Animal Models, 3D Bioprinting

2) By Application: Educational, Drug Discovery, Other Applications

3) By End Users: Research Institutes, Pharmaceutical Companies, Other End Users

Subsegments:

1) By Liver Organoids: Primary Liver Organoids, Induced Pluripotent Stem Cell (iPSC)-Derived Organoids

2) By Liver-On-A-Chip: Microfluidic Liver Chips, Multi-Organ Chip Systems

3) By 2D Models: Liver Cell Cultures, Liver Cell Lines

4) By Animal Models: Rodent Models, Large Animal Models

5) By 3D Bioprinting: Bioprinted Liver Tissues, Hybrid Bioprinted Models

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Who are the key firms paving the way for growth in the human liver model market?

Major companies operating in the human liver model market include Corning Incorporated, EISCO Scientific LLC, BioIVT LLC, Cyprotex plc, Emulate Inc., Cellink AB, Nortis Inc., InSphero AG, CN Bio Innovations Ltd., TissUse GmbH, Ascendance Biotechnology Inc., HemoShear Therapeutics Inc., Cyfuse Biomedical, MIMETAS BV, Biopredic International Sarl, ZenBio, Hurel Corporation, Regenovo, Pandorum, Organovo Holdings Inc., BICO Group, Hepregen Corporation, Kirkstall Ltd., HepaLife Technologies Inc., Cellaïon SA.

Which trends are expected to transform the human liver model market?

The rising trend of product innovation is becoming increasingly noticeable within the human liver model market. Leading companies in this field are focusing on the development of novel products to secure their market position. A prime example, in April 2023, LifeNet Health Life Sciences, an American company specializing in human cell and tissue-based solutions, introduced TruVivo, an innovative liver system composed entirely of human cells. This product is set to play a vital role in the research and development of new drugs and compounds. This groundbreaking 2D+ solution skillfully merges the comprehensive data associated with 3D models and the ease of use typically associated with 2D models.

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What regions are contributing significantly to the growth of the human liver model market?

North America was the largest region in the human liver model market in 2024. The regions covered in the human liver model market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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