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What fueled the previous growth in the in situ hybridization market?

The market size for in situ hybridization has seen significant expansion lately. It’s projected to increase from $1.68 billion in 2024 to $1.83 billion in 2025, with a compound annual growth rate (CAGR) of 8.9%. The historical growth can be tied back to the early implementation in research studies, the progression of molecular biology utilities, the creation of diagnostic applications, a shift towards biomedical research, and boosted investments in biotechnology.

What will be the in situ hybridization market size in the future?

The market size for in situ hybridization is predicted to experience accelerated expansion in the upcoming years, reaching $2.79 billion in 2029 with a Compound Annual Growth Rate (CAGR) of 11.2%. This projected growth within the forecast period can be linked to its increased acceptance in clinical diagnostics, a surge in research and development funds, automated and high-capacity solutions, along with widened applications in neuroscience and pathology. The forecast period will exhibit significant trends which include molecular biology advancements, a burgeoning demand in research applications, the expansion of diagnostic applications, rising demand for personalised medicine, and a surge in funding for biomedical research.

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What main drivers are fueling expansion in the in situ hybridization market?

Expectations are for the in-situ hybridization market to expand due to the rise in infectious diseases. These diseases, which stem from contaminated food and drink as well as pathogens like bacteria, viruses, fungi, and parasites, are those that can pass from one person to another. To identify corresponding nucleic acid sequences present in the tissue, in-situ hybridization (ISH) uses nucleic acid sequences specific to the infectious agents, thereby bringing a boost to the in-situ hybridization market when infectious disease rates rise. For example, statistics from the US Centers for Disease Control and Prevention highlight this: in March 2024, tuberculosis cases increased to 9,615 from 8,320 in 2022 – that’s a rise of 1,295 cases. It is, therefore, clear to see that the upsurge in infectious diseases is fuelling the growth of the in-situ hybridization market.

What key areas define the segmentation of the global in situ hybridization market?

The in situ hybridization market covered in this report is segmented –

1) By Product: Analytical Instruments, Kits and Reagents, Software and Services, Other Products

2) By Technique: Fluorescence In Situ Hybridization (FISH), Chromogenic In Situ hybridization (CISH)

3) By Probe: Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA)

4) By Application: Cancer, Cytogenetics, Developmental Biology, Infectious Diseases, Other Applications

5) By End Use: Research And Diagnostic Laboratories, Contract Research Organization (CROs), Academic Institutes, Other End Uses

Subsegments:

1) By Analytical Instruments: Fluorescence Microscopes, Imaging Systems, Hybridization Systems

2) By Kits and Reagents: Hybridization Kits, Detection Kits, Probes And Reagents

3) By Software and Services: Image Analysis Software, Data Management Software, Consulting And Support Services

4) By Other Products: Accessories, Control Samples, Maintenance Supplies

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Who are the dominant players expanding their reach in the in situ hybridization market?

Major companies operating in the in situ hybridization market include Thermo Fisher Scientific Inc., Bio SB Inc., BioGenex Laboratories, Advanced Cell Diagnostics Inc., Exiqon A/S, Agilent Technologies Inc., F. Hoffmann-La Roche AG, Abbott Laboratories Inc., Merck KGaA, PerkinElmer Inc., Biocare Medical LLC, Genemed Biotechnologies, Danaher Corporation, Leica Biosystems Nussloch GmbH, Bio-Rad Laboratories Inc., Oxford Gene Technology, Abnova Corporation, Qiagen, Bio-Techne Corporation, Biochain Institute Inc., Cytocell Ltd., Enzo Life Sciences Inc., Eurofins Scientific SE, FISH Technologies Sdn Bhd, Genetix Biotech Asia Pvt. Ltd., Zytomed System GmbH, Akoya Biosciences Inc., Becton Dickinson and Company (BD), DAKO Systemtechnik und Service GmbH & Co, Molecular Devices LLC., NanoString Technologies Inc., Visiopharm A/S

How are evolving market trends shaping in situ hybridization Strategies?

Leading enterprises in the in situ hybridization market are pioneering new solutions including RNA detection assays, to progress the development of gene therapy. RNA detection assays are typically molecular methodologies employed to recognize and calculate the number of certain RNA molecules present in any given sample, aiding research on gene expression, viral diseases, and various other RNA-associated biological activities. As an illustration, in January 2023, Bio-Techne Corporation, an American life sciences enterprise, introduced the RNAscope Plus smRNA-RNA detection assay. This enhanced in situ hybridization instrument allows simultaneous fluorescent identification of small regulatory RNAs like microRNAs (miRNAs), and up to three target RNAs or RNA biomarkers in the same tissue slice. The assay delivers single-cell and subcellular resolution, making it easier for scientists to comprehensively evaluate the characteristics and spatial distribution of novel gene therapies and endogenous regulatory RNAs. It has the capacity to cater to sizable studies and can be used on the Leica Bond Rx platform or manually. The integration of proprietary RNAscope and miRNAscope technologies in this assay pushes forward the comprehension of gene expression and cellular responses, delivering valuable insights for the creation of bespoke gene therapies for congenital or developed diseases.

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Which regions are emerging as leaders in the in situ hybridization market?

North America was the largest region in the in situ hybridization market in 2024. Asia-Pacific is expected to be the fastest-growing region in the global in situ hybridization market during the forecast period. The regions covered in the in situ hybridization market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa

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