How is the Ligases Enzyme Market Poised for Growth: Trends and Opportunities Through 2034
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How has the ligases enzyme market grown over the years?
The market for ligases enzyme has seen a rapid expansion in size over recent years. The sector, valued at $3.23 billion in 2024, is projected to escalate to $3.58 billion in 2025, achieving a compound annual growth rate (CAGR) of 10.8%. The growth during the historical period can be ascribed to the early finding and development of ligase enzymes, the evolution of the biotechnology industry, improved comprehension of DNA repair processes, the broadening scope of genetic engineering applications, and the surge in requirement for molecular diagnostics.
What Is the forecasted market size and growth rate for the ligases enzyme market?
Rapid expansion can be anticipated in the market size for the ligase enzyme in the coming years, with projections for it to reach $5.64 billion in 2029 at a 12.0% compound annual growth rate (CAGR). The surge expected during the forecast period can be credited to various factors such as the growing application spectrum of personalized medicine, an increased focus on synthetic biology, the use of ligase enzymes in drug research, rising demand for molecular diagnostics, and the integration of ligases into next-gen sequencing. Prominent trends likely to appear during the forecast period include the crafting of engineered ligases tailored for specific purposes, the incorporation of ligase enzymes into CRISPR-based technologies, adaptations of ligase-based assays specifically for research and diagnostics, an upswing in ligase-based isothermal amplification methods, and the usage of ligase chain reaction (LCR) within diagnostic assays.
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What are the major factors driving growth in the ligases enzyme market?
The ligase enzyme market is expected to experience significant growth due to the escalating occurrence of cancer and genetic disorders. Cancer is a cluster of diseases typified by the unchecked proliferation and distribution of abnormal cells. Genetic disorders are a vast array of medical conditions triggered by irregularities or changes in a person’s genetic code, notably in their DNA. Ligase enzymes play a crucial role in DNA replication, reparation, and recombination. These enzymes can address damaged DNA in cancer, leading to the unrestrained propagation of cells. They can also target and eliminate cells inflicted with genetic disorders. For example, the Australian Institute of Health and Welfare, an Australia-based government institution, reported in July 2024 that the volume of diagnosed cancer cases in Australia grew from 160,570 in 2022 to 164,694 in 2023, demonstrating a substantial increase over the year. This surge underscores the escalating occurrence of cancer within the nation. Moreover, 403 new cases of cancer and 144 cancer-linked fatalities were recorded for every 100,000 individuals. In addition, according to Gene People UK, a registered charity group in the UK, it was observed that roughly 1 in 25 children in the UK are impacted by a genetic condition. This translates to over 2.4 million children and adults living with a genetic disorder in the UK, with 30,000 babies and children being newly diagnosed every year. Consequently, the rising incidence of cancer and genetic disorders is propelling the growth of the ligase enzyme market.
What key areas define the segmentation of the global ligases enzyme Market?
The ligases enzyme market covered in this report is segmented –
1) By Type: E. coli DNA ligase, T4 DNA Ligase, Mammalian Ligases, Thermostable Ligases
2) By Source: Microorganisms, Animal, Plant
3) By Application: Ligase Chain Reaction (LCR), Ligase Detection Reaction (LDR), Next-Generation Sequencing (NGS), Repeat Expansion Detection (RED), Rolling Circle Amplification (RCA), Proximity Ligation Assay (PLA), Molecular Cloning, Ligation Mediated PCR, Mutation Detection
4) By End-User: Research Laboratories And Institutions, Pharmaceutical And Biopharmaceutical Companies, Diagnostic Laboratories
Subsegments:
1) By E. coli DNA Ligase: Ligase I, Ligase II
2) By T4 DNA Ligase: Wild-Type T4 Ligase, Modified T4 Ligase
3) By Mammalian Ligases: Ligase IV, Ligase I
4) By Thermostable Ligases: Taq DNA Ligase, Pyrococcus Furiosus Ligase
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What are the top market players propelling the growth of the ligases enzyme industry?
Major companies operating in the ligases enzyme market include BASF SE, F. Hoffmann-La Roche AG, Thermo Fisher Scientific Inc., Merck KGaA, Agilent Technologies Inc., Illumina Inc., QIAGEN N.V., GenScript, Promega Corporation, Oxford Nanopore Technologies Limited, Takara Bio Inc., New England Biolabs Inc., BioVision Inc., Enzo Life Sciences, Zymo Research, LGC Biosearch Technologies, Genetix Biotech Asia Pvt. Ltd., BLIRT S.A., Jena Bioscience, Bioline, Creative Enzymes, ArcticZymes Technologies ASA
What are the key trends shaping the future of the ligases enzyme market?
Leading firms in the ligases enzyme market are advancing technologies like nanopore methods to heighten the accuracy and competence of DNA sequencing and handling, subsequently uplifting their use in genomics, bespoke medicine, and synthetic biology. Nanopore procedures incorporate the application of nanopores for identifying and examining molecules, including DNA or proteins, by observing variances in ionic current when these travel through the pore. For example, during February 2023, Eurofins Genomics, a biotech corporation based in the US, initiated the Express Oxford Nanopore Sequencing service. This service employs Oxford Nanopore technology, permitting the sequencing of extended DNA segments. This feature is particularly advantageous for tasks demanding thorough genomic evaluation, like metagenomics and detection of structural variants.
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What regions are dominating the ligases enzyme market growth?
North America was the largest region in the ligases enzyme market in 2024. Asia-Pacific is expected to be the fastest-growing region in the ligases enzyme market report during the forecast period. The regions covered in the ligases enzyme market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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