Methylmalonic Acidemia (MMA) Global Market Report 2025 Market Insights: In-Depth Look at Growth Trends, Market Size, and Opportunities for 2025-2034
2025 Market Reports Update: Market Size Forecasts to 2034, Key Trends, Leading Players, and Top Regions – Get Ahead of the Competition Today!
How Are Key Drivers Contributing to the Growth and Expansion of the Methylmalonic Acidemia (MMA) Market?
The upward trend in metabolic disorders and deficiencies in vitamins is anticipated to spur the methylmalonic acidemia (MMA) market’s expansion in the future. These metabolic disorders consist of a collection of conditions where the body struggles with processing certain nutrients, creating energy, or managing chemical reactions inside cells. Deficiencies in vitamins emerge when specific vitamins needed for regular bodily functions are in short supply. Unhealthy diets, a lack of physical activity, and heightened stress levels have led to an increase in these health issues. Current diets are typically filled with processed foods, sugars, and unhealthy fats, but are deficient in vital nutrients. This leads to a lack of vitamins and minerals. Metabolic disorders and deficiencies in vitamins, especially a lack of vitamin B12, can interfere with methylmalonyl-CoA metabolism, leading to a buildup of methylmalonic acid and worsening methylmalonic acidemia (MMA). In a notable example, the National Institutes of Health, a government agency in the US, reported in November 2024 that there had been a rise in vitamin B12 deficiency cases from 4.6% to 5.2%, which indicates an extra 507 cases between the third and fourth quarters of 2023. As such, the rising occurrence of metabolic disorders and vitamin deficiencies is driving the expansion of the methylmalonic acidemia (MMA) market.
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#What Long-Term Growth Rate is Expected for theMethylmalonic Acidemia (MMA) Market Between 2025 and 2034?
In recent years, the size of the methylmalonic acidemia (MMA) market has seen robust growth. It is projected to expand from $9.39 billion in 2024 to $9.97 billion in 2025, with a compound annual growth rate (CAGR) of 6.2%. The growth witnessed in the historic period is due to factors such as a rising number of metabolic disorders and vitamin deficiencies, heightened health consciousness, an upswing in healthcare spending, increasing instances of genetic disorders, and a growing demand from several end-user industries.
In the forthcoming years, the Methylmalonic Acidemia (MMA) market is projected to experience robust growth. By the year 2029, its worth is anticipated to reach $12.50 billion, with a Compound Annual Growth Rate (CAGR) of 5.8%. Various factors, such as the proliferation of newborn screening programs, amplified awareness among medical professionals, gene therapy advancements, amplified funding for rare disease studies, and increased accessibility to specialized treatments, contribute to this growth during the forecast period. The forecast period is also expected to see trends like the progress in gene editing technologies, enhanced diagnostic techniques for early detection, the evolution of enzyme replacement therapies, precision medicine uptake, and the utilization of newborn genetic screening programs.
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What New Market Trends Are Reshaping the Methylmalonic Acidemia (MMA) Market and Its Opportunities?
In the methylmalonic acidemia (MMA) market, prominent businesses are emphasizing on the creation of groundbreaking solutions like mRNA-based therapies. Their goal is to enhance treatment results by focusing on the genetic roots of MMA and boosting enzyme activity to minimize the buildup of harmful metabolites in those affected. mRNA-based treatments operate by deploying messenger RNA to instruct cells to manufacture specific proteins, which can play a crucial role in combating diseases like genetic anomalies or infections. For instance, the US pharmaceutical and biotechnology company Moderna, Inc., got a nod from the U.S. Food and Drug Administration (FDA) in June 2024, to incorporate mRNA-3705 into its START pilot program. This critical milestone has aided in the progression of therapies for rare diseases. mRNA-3705, an experimental treatment for MMA caused by MUT deficiency, aims to replenish the absent enzyme through mRNA technology. Besides, RNA-3705’s development and clinical advancements have been expedited by the FDA, as it has been granted orphan drugs, fast track, and rare pediatric disease statuses. The treatment also capitalizes on Moderna’s proprietary lipid nanoparticle (LNP) system, used in their mRNA-3927 program for propionic acidemia.
Who Are the Leading Market Players Fueling Growth in the Methylmalonic Acidemia (MMA) Market Trend?
Major companies operating in the methylmalonic acidemia (MMA) market are Moderna Inc., Lonza Group Ltd., Alexion Pharmaceuticals Inc., PTC Therapeutics Inc., Ironwood Pharmaceuticals Inc., Wockhardt Limited, Spectrum Chemical Manufacturing Corp., Asklepios BioPharmaceutical Inc. (AskBio), Selecta Biosciences Inc., BTG International Inc., BridgeBio Pharma Inc., VectivBio Holding AG, Supriya Lifescience Ltd., Recordati Rare Diseases Inc., Agios Pharmaceuticals Inc., AdvaCare Pharma USA LLC, LogicBio Therapeutics Inc., HemoShear Therapeutics LLC, Manus Aktteva Biopharma LLP, Deccan Nutraceuticals Pvt. Ltd.
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How is the Global Methylmalonic Acidemia (MMA) Market Segemented?
The methylmalonic acidemia (MMA) market covered in this report is segmented –
1) By Indication: Acidosis, Ketosis, Hyperammonemia, Hypoglycaemia, Hyperglycaemia, Neutropenia, Other Indications
2) By Disorder Type: Homocystinuria, Isolated Methylmalonic Acidurias, Combined methylmalonic Aciduria
3) By Distribution Channel: Hospitals, Pharmacies, Clinics, Other Distribution Channels
Subsegments:
1) By Acidosis: Metabolic Acidosis, Lactic Acidosis
2) By Ketosis: Starvation-Induced Ketosis, Diabetic Ketoacidosis
3) By Hyperammonemia: Acute Hyperammonemia, Chronic Hyperammonemia
4) By Hypoglycemia: Fasting Hypoglycemia, Reactive Hypoglycemi
5) By Hyperglycemia: Transient Hyperglycemia, Persistent Hyperglycemia
6) By Neutropenia: Severe Neutropenia, Cyclic Neutropenia
7) By Other Indications: Failure to Thrive, Developmental Delays, Neurological Symptoms, Renal Dysfunction
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Which Geographics are Influencing the Growth of the Methylmalonic Acidemia (MMA) Market?
North America was the largest region in the methylmalonic acidemia (MMA) market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the methylmalonic acidemia (MMA) market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
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