2025 Market Reports Update: Market Size Forecasts to 2034, Key Trends, Leading Players, and Top Regions – Get Ahead of the Competition Today!

How Are Key Drivers Contributing to the Growth and Expansion of the Nucleic Acid Based Gene Therapy Market?

Increasing government and corporate financial support is expected to drive the demand for nucleic acid-based gene therapy. These therapies, targeting the genetic causes of diseases, offer potential cures for conditions like cystic fibrosis, sickle cell anemia, and diabetes. Government funding, such as the $34 million annual investment announced by the NIH in 2022 for HIV research, is driving the development of gene therapies. This financial backing is expected to contribute to the growth of the nucleic acid-based gene therapy market.

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#How Does the ProjectedNucleic Acid Based Gene Therapy Market Growth Compare Over the Forecast Period?

The nucleic acid-based gene therapy market size has grown strongly in recent years. It will grow from $0.81 billion in 2024 to $0.88 billion in 2025, at a compound annual growth rate (CAGR) of 9.4%. This growth can be attributed to the growing understanding of human genetics, the demand for personalized medicine, the expanding pipeline of gene therapy products, and government support for genetic disorders and cancer therapy.

The nucleic acid based gene therapy market is expected to grow swiftly, reaching $1.33 billion in 2029 at a CAGR of 10.7%. Growth will be supported by an expanding range of treatment areas, greater investment, increased awareness through patient advocacy, and focused R&D in gene therapies, especially for rare diseases. Emerging trends include ex vivo and in vivo gene editing progress, combination treatment approaches, precise delivery systems, and non-viral vector innovations.

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What Are the Most Significant Market Trends Transforming theNucleic Acid Based Gene Therapy Market?

In March 2023, Moderna, Inc., a US-based biotechnology company, partnered with Generation Bio to develop novel nucleic acid therapeutics capable of targeting immune cells. The collaboration aims to accelerate both companies’ pipelines of non-viral genetic medicines. Generation Bio, also based in the US, specializes in nucleic acid-based gene therapy, and the partnership will fund all associated R&D efforts, including a pre-payment for research activities.

Who Are the Leading Market Players Fueling Growth in the Nucleic Acid Based Gene Therapy Market Trend?

Major companies operating in the nucleic acid based gene therapy market include Celsion Corporation, Wave Life Sciences, Imugene Ltd., Caperna LLC, Phylogica Limited, Protagonist Therapeutics Inc., Benitec Biopharma Ltd., EGEN, BioMedica, Transgene SA, Copernicus Therapeutics Inc., 4D Molecular Therapeutics Inc., Abeona Therapeutics Inc., Alnylam Pharmaceuticals Inc., Amgen Inc., Beam Therapeutics Inc., BioNTech SE, Bluebird Bio Inc., CRISPR Therapeutics AG, Editas Medicine Inc., Genevant Sciences Inc., Homology Medicines Inc., Intellia Therapeutics Inc., Ionis Pharmaceuticals Inc., MaxCyte Inc., Moderna Inc., Novartis International AG, Orchard Therapeutics plc, Precision BioSciences Inc., REGENXBIO Inc.

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How is the Global Nucleic Acid Based Gene Therapy Market Segemented?

The nucleic acid based gene therapy market covered in this report is segmented –

1) By Technology: Anti-Sence and Anti-Gene, Short Inhibitory Sequences, Gene Transfer Therapy, Nucleoside Analogs, Ribozymes, Aptamers, Other Technologies

2) By Application: Oncology, Muscular Dystrophy/ Muscular Disorders, Rare Diseases

3) By End User: Hospitals And Clinics, Academic And Research Institutes

Subsegments:

1) By Anti-Sense And Anti-Gene: Oligonucleotide Therapeutics, Peptide Nucleic Acids (PNA), Morpholino Oligomers (MO)

2) By Short Inhibitory Sequences (siRNA): Synthetic siRNA, Encapsulation/Delivery Systems for siRNA, Target-specific siRNA Therapies

3) By Gene Transfer Therapy: Viral Vectors (Adenovirus, Lentivirus, Retrovirus, AAV), Non-Viral Vectors (Liposomes, Electroporation, Gene Gun)

4) By Nucleoside Analogs: Purine Analogs, Pyrimidine Analogs

5) By Ribozymes: Trans-Splicing Ribozymes, Hammerhead Ribozymes

6) By Aptamers: RNA Aptamers, DNA Aptamers, Small Molecule Binding Aptamers

7) By Other Technologies: CRISPR-based Gene Editing, Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector Nucleases (TALENs)

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Which Geographics are Influencing the Growth of the Nucleic Acid Based Gene Therapy Market?

North America was the largest region in the nucleic acid-based gene therapy market in 2023. Western Europe was the second-largest region in the nucleic acid-based gene therapy market report. The regions covered in the nucleic acid based gene therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, and Africa.

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