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How has the oligonucleotide synthesis market size evolved in recent years?

The market size for oligonucleotide synthesis has significantly expanded in the past few years. The market is set to rise from a worth of $10.33 billion in 2024 to an impressive $11.94 billion in 2025, yielding a compound annual growth rate (CAGR) of 15.6%. The expansion during the historical period can be traced back to progressive advancements in biomedical research, therapeutic development, innovation in biotechnology, genomic investigations, and an upsurge in DNA technologies.

What are the predictions for the oligonucleotide synthesis market size in the coming years?

In the upcoming years, the oligonucleotide synthesis market size is projected to witness quick expansion. The market size is forecasted to reach $22.29 billion in 2029 with a compound annual growth rate (CAGR) of 16.9%. The surge during the forecast period can be credited to the emergence of diagnostic tools, RNA interference (RNAi) therapies, regenerative medicine, the application of nanotechnology, and progress in gene editing. The forecast period will likely see trends such as specifically targeted drug development, groundbreaking delivery systems, automated synthesis, CRISPR-cas technology, and next-generation sequencing (NGS).

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What key factors are fueling the growth of the oligonucleotide synthesis market?

The escalating occurrence of chronic illnesses is projected to spur the expansion of the oligonucleotide synthesis market in the future. Chronic diseases are conditions that persist for over a year and demand constant medical care, and they can potentially deteriorate over time. Oligonucleotides influence the gene expression that leads to these chronic conditions through various methods. They can influence mRNA, pre-mRNA, or non-coding RNA to alter splicing events, instigate degradation, or obstruct protein translation. For example, in September 2022, the World Health Organization, a specialised agency of the United Nations based in Switzerland, reported 41 million fatalities, accounting for 74% of deaths triggered by non-communicable diseases (NCDs) or chronic diseases worldwide every year. The figures included 17.9 million deaths from cardiovascular diseases, 9.3 million from cancer, 4.1 million from chronic respiratory diseases, and 2.0 million from diabetes. Hence, the increasing occurrence of chronic and rare illnesses is fuelling the growth of the oligonucleotide synthesis market.

How is the global oligonucleotide synthesis market divided into key segments?

The oligonucleotide synthesis market covered in this report is segmented –

1) By Type: Custom Oligos, Predesigned Oligos

2) By Product Type: Oligonucleotides, Reagents, Equipment, Services, Purification, Modification

3) By Application: Therapeutic Applications, Research Applications, Diagnostic Applications

Subsegments:

1) By Custom Oligos: Long Oligonucleotides, Short Oligonucleotides, Modified Oligonucleotides

2) By Predesigned Oligos: Gene-Specific Oligos, Probe Oligos, Primers For PCR And RT-PCR

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Who are the key firms paving the way for growth in the oligonucleotide synthesis market?

Major companies operating in the oligonucleotide synthesis market include Thermo Fisher Scientific Inc., Danaher Corporation, Merck KGaA, GE HealthCare Technologies Inc., Eurofins Scientific SE, Agilent Technologies Inc., Nitto Denko Avecia Inc., Alnylam Pharmaceuticals Inc., Maravai Life Sciences, LGC Limited, Ionis Pharmaceuticals Inc., GenScript Inc., Ajinomoto Bio-Pharma Services, Sarepta Therapeutics Inc., Integrated DNA Technologies Inc., Twist Bioscience Corporation, Eurogentec SA, Kaneka Eurogentec S.A., Biocomma Limited, Bio-Synthesis Inc., TriLink BioTechnologies Incorporated, Generi Biotech s.r.o., ATDBio Ltd., BioAutomation Corporation, Biolegio B.V., Dharmacon Research Inc.

Which trends are expected to transform the oligonucleotide synthesis market?

In the oligonucleotide synthesis market, the trend that is gaining significant traction revolves around product innovation. To stay competitive, leading corporations are introducing novel products. For instance, Ansa Biotechnologies, Inc., a US firm that specializes in complex DNA production, rolled out Ansa Clonal DNA and Ansa DNA Fragments in July 2024. The former is capable of providing clonal, sequence-perfect DNA up to 600 base pairs long, thus eliminating assembly requirements and providing unmatched accuracy for intricate synthetic biology projects. This product guarantees error-free and ready-for-use DNA sequences, making it a dependable option for scientists. On the other hand, Ansa DNA Fragments provide sequence-verified linear double-stranded DNA fragments up to 600 base pairs, custom-made for various research purposes. By employing an innovative enzymatic synthesis method, Ansa consistently produces complex DNA constructs, such as repeats and secondary structures, with extreme precision.

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What regions are contributing significantly to the growth of the oligonucleotide synthesis market?

North America was the largest region in the oligonucleotide synthesis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the oligonucleotide synthesis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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