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How has the prescription orthopedic drugs market size evolved in recent years?

The orthopedic medication market has seen significant expansion in recent years, escalating from $48.41 billion in 2024 to an estimated $51.55 billion in 2025. This growth, representing a compound annual growth rate (CAGR) of 6.5%, is attributable to several key factors. These include a heightened incidence of musculoskeletal disorders, a surge in the elderly population, increased awareness of osteoporosis treatments, broader access to healthcare in less developed areas, and a rise in sports-related injuries globally.

What are the predictions for the prescription orthopedic drugs market size in the coming years?

The market size for prescription orthopedic medication is projected to witness significant expansion in the coming years, rising to $65.32 billion in 2029 with a 6.1% compound annual growth rate (CAGR). Various factors could contribute to this growth including an elevating demand for biological medications, an increasing aging population, broader healthcare accessibility in emerging markets, escalating instances of chronic musculoskeletal disorders, and an upsurge in funding for orthopedic drug research and development. The forthcoming years are also expected to see pervasive trends such as progress in targeted biological medicines, the implementation of regenerative medicine therapies, customization in drug formulations, breakthroughs in minimally invasive delivery techniques, a boost in drug efficiency using gene therapy, advancements in injectable formulations, and the introduction of artificial intelligence to aid drug development and clinical decision-making processes.

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What key factors are fueling the growth of the prescription orthopedic drugs market?

The rise in musculoskeletal disorders is anticipated to push the expansion of the prescription orthopedic drugs market. Musculoskeletal disorders, (MSDs) conditions and injuries that hinder the function and movement of the body’s musculoskeletal system comprising muscles, tendons, ligaments, nerves, and joints, lead to pain and limited mobility. The surge in these disorders is largely due to factors like aging, repetitive and awkward postures in occupational activities, lifestyle habits such as poor nutrition and physical inactivity, and genetic predispositions. Prescription orthopedic drugs are key in handling these disorders as they alleviate pain, decrease inflammation, and aid the healing process, thus boosting mobility and overall life quality. As an example, the Office for Health Improvement and Disparities, a government department for public health in the UK, stated in March 2023 that in 2022, there was a rise in long-term musculoskeletal conditions, such as ongoing back or joint issues or arthritis, in individuals aged 16 and over from 17.0% in 2021 to 17.6%. Furthermore, the World Health Organization, a Switzerland-based intergovernmental organization, reported in July 2022 that around 1.71 billion people globally were suffering from musculoskeletal disorders. Consequently, the rising prevalence of musculoskeletal disorders is propelling the growth of the prescription orthopedic drugs market.

How is the global prescription orthopedic drugs market divided into key segments?

The prescription orthopedic drugs market covered in this report is segmented –

1) By Drug Type: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), Opioids, Corticosteroids, Disease-Modifying Antirheumatic Drugs (DMARDs), Other Drug Types

2) By Application: Osteoarthritis, Rheumatoid Arthritis, Osteoporosis, Other Applications

3) By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies

Subsegments:

1) By Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Ibuprofen, Naproxen, Diclofenac, Celecoxib, Indomethacin

2) By Opioids: Morphine, Oxycodone, Hydrocodone, Fentanyl, Tramadol

3) By Corticosteroids: Prednisone, Methylprednisolone, Dexamethasone, Hydrocortisone, Betamethasone

4) By Disease-Modifying Antirheumatic Drugs (DMARDs): Methotrexate, Hydroxychloroquine, Leflunomide, Sulfasalazine, Azathioprine

5) By Other Drug Types: Bisphosphonates, Calcitonin, Monoclonal Antibodies, Muscle Relaxants, Hyaluronic Acid Injections

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Who are the key firms paving the way for growth in the prescription orthopedic drugs market?

Major companies operating in the prescription orthopedic drugs market are Pfizer Inc., Johnson & Johnson, Roche Holding AG, Merck KGaA, AbbVie Inc., Bayer AG, Sanofi S.A., Bristol-Myers Squibb Company, AstraZeneca plc, GSK Plc, Takeda Pharmaceutical Company Limited, Eli Lilly and Company, Amgen Inc., Teva Pharmaceutical Industries Ltd., Mylan N.V., Biogen Inc., UCB S.A., Allergan plc, Penardo Biotech Pvt. Ltd., Horizon Therapeutics plc

What are the key trends shaping the future of the prescription orthopedic drugs market?

Leading companies in the market for prescription orthopedic drugs are working towards extending the approved indications for their drugs. The intent is to widen their market penetration, improve patient results, and cater to the unaddressed medical needs in the realm of various orthopedic disorders. For example, Heron Therapeutics Inc., an American biotech firm, gained FDA endorsement in January 2023 for the broader use of ZYNRELEF (bupivacaine and meloxicam). This includes its application in soft tissue, and orthopedic procedures such as foot and ankle surgeries. This innovative extended-release formula is inherently crafted to offer extended pain relief, lasting up to 72 hours. This potentially reduces, if not eradicates, the post-surgical dependence on opioids. The newly expanded authorization now includes more orthopedic and soft tissue procedures, making it even more relevant in clinical applications. The pioneering combination of local anesthetic and anti-inflammatory properties positions it as a comprehensive solution for managing post-operative pain, improving patient outcomes in the process.

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What regions are contributing significantly to the growth of the prescription orthopedic drugs market?

North America was the largest region in the prescription orthopedic drugs market in 2024. The regions covered in the prescription orthopedic drugs market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

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