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How has the upstream bioprocessing market size evolved in recent years?

The size of the upstream bioprocessing market has experienced significant growth over the past few years. The market value is projected to increase from $12.03 billion in 2024 to $13.66 billion in 2025, marking a compound annual growth rate (CAGR) of 13.6%. This escalation during the historic period is related to increased attention towards process optimization, clean and efficient production of biomolecules, commercial accomplishments, and growing demand for bio-therapeutics. Other contributing factors include the increased use of process analytical technology, rising prevalence of chronic diseases, and heightened research into the production of biosimilars.

What are the predictions for the upstream bioprocessing market size in the coming years?

The market size of upstream bioprocessing is poised for a significant expansion in the coming years, with predictions pointing towards a growth to $22.43 billion in 2029. This will be at a compound annual growth rate (CAGR) of 13.2%. The surge during the projected years could be because of the commercial applications of single-use bioreactors, the externalization of biopharmaceutical production, the escalation of the pharmaceutical and biotechnology sectors, the increased preference for single-use upstream bioprocessing, along with a rise in partnerships and corporate actions like mergers, acquisitions and collaborations. The forecast period is set to witness trends such as escalating investments in R&D within the biopharmaceutical realm, technological progression, advanced upstream bioprocessing solutions, as well as the advent of novel technologies and sophisticated filtration methods.

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What key factors are fueling the growth of the upstream bioprocessing market?

The anticipated increase in the upstream bioprocessing market is largely attributed to the outsourcing of biopharmaceutical manufacturing. This involves assigning certain elements of the manufacturing process to external parties such as contract manufacturing organizations (CMOs) or contract development and manufacturing organizations (CDMOs). The driving forces behind the outsourcing of biopharmaceutical manufacturing include cost-effectiveness, focusing on essential competencies, scalability in production, access to specialized skills, and risk reduction. Product development in the upstream bioprocessing market is expedited by outsourcing biopharmaceutical manufacturing, allowing for operational streamlining, cost reduction, and utilization of external expertise. BDO USA, a branch of BDO International predicts that by 2025, 44% of the projected 7,500kL global mammalian capacity will be controlled by contract development and manufacturing organizations, and hybrid manufacturing companies. As a result, the growth of the upstream bioprocessing market is being propelled by the outsourcing of biopharmaceutical manufacturing.

How is the global upstream bioprocessing market divided into key segments?

The upstream bioprocessing market covered in this report is segmented –

1) By Product type: Bioreactors, Fermenters, Cell Culture Media, Filters, Bags And Containers

2) By Workflow: Media Preparation, Cell Culture, Cell Separation

3) By Usage type: Single-Use, Multi-Use

4) By Mode: In House, Outsourced

5) By End User: Contract Development and Manufacturing Organization (CDMOs) Or Contract Research Organization (CROs), Research And Academic Institutes, Biopharmaceutical Companies

Subsegments:

1) By Bioreactors: Single-Use Bioreactors, Multi-Use Bioreactors

2) By Fermenters: Laboratory Fermenters, Pilot Scale Fermenters, Industrial Fermenters

3) By Cell Culture Media: Powdered Media, Liquid Media

4) By Filters: Sterile Filters, Air Filters, Capsule Filters

5) By Bags And Containers: Single-Use Bags, Bioprocess Containers, Storage Bags

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Who are the key players steering the development of the upstream bioprocessing market?

Major companies operating in the upstream bioprocessing market are Thermo Fisher Scientific Inc., Danaher Corp, Merck KGaA, GE HealthCare Technologies, Parker Hannifin Corp, Corning Inc., AGC Biologics, Avantor, AGC Inc., Boehringer Ingelheim International GmbH, Catalent Inc., Sartorius AG, Entegris Inc., Getinge AB, Bio-Rad Laboratories Inc., Samsung Biologics Co. Ltd., Eppendorf AG, Repligen Corporation, Takara Bio Inc., KBI Biopharma Inc., Rentschler Biopharma SE, Just Biotherapeutics Inc., PBS Biotech Inc., Stobbe Group, Applikon Biotechnology

What are the key trends shaping the future of the upstream bioprocessing market?

The primary focus of significant players in the upstream bioprocessing industry is the development of state-of-the-art bioreactors that cater to the requirements of cell culture procedures, enhancing performance, adaptability, and scalability. Bioreactors play a crucial role in upstream bioprocessing, facilitating the effective and regulated production of biopharmaceuticals via cell culture and biomolecule generation. As an illustration, Cytiva, an American firm providing life science products and solutions, launched X-platform bioreactors in April 2023. These bioreactors are intended to simplify single-use upstream bioprocessing operations. The bioreactors are comprised of a tank, cabinet assembly, and a human-machine interface (HMI). Their modular design allows for adaptable configurations without the need for custom hardware or single-use bags. They have user-friendly attributes like an optimized vessel with a fully opening door, baffles, and enhanced cable management. Moreover, the Bioreactor Scaler tool provided online aids in determining the ideal parameters for successful scale-up.

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Which regions are most influential in expanding the upstream bioprocessing market?

North America was the largest region in the upstream bioprocessing market in 2023. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the upstream bioprocessing market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East and Africa.

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